(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide
SUBSTANCE P
CAS: 33507-63-0
Molecular Formula: C63H98N18O13S
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide - Names and Identifiers
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide - Physico-chemical Properties
| Molecular Formula | C63H98N18O13S |
| Molar Mass | 1347.63 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 148 °C |
| Water Solubility | Soluble in water, DMSO, and Acetic Acid. |
| Solubility | H2O: 1mg/mL |
| Appearance | Form powder, color white |
| Color | white |
| pKa | 13.26±0.46(Predicted) |
| Storage Condition | −20°C |
| Physical and Chemical Properties | Chemical properties of white freeze-dried powder, easily soluble in water, high-purity aqueous solution is easy to inactivate, adding Tween 80, gelatin, human plasma albumin or bovine gamma globulin can increase its stability; pH is greater than 8 It is unstable and inactivated by pepsin and chymotrypsin; it should be stored in a low pH value, and filled with nitrogen or added with antioxidants to avoid its inactivation. |
| Use | Uses for biochemical research, medicine used as vasodilator, nerve tuning agent, can promote saliva secretion, increase capillary permeability, can cause smooth muscle contraction, blood pressure reduction and stimulate the secretion of tissue, it plays a role in the transmission of pain. |
| In vitro study | The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells. |
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide - Risk and Safety
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10-21 |
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.742 ml | 3.71 ml | 7.42 ml |
| 5 mM | 0.148 ml | 0.742 ml | 1.484 ml |
| 10 mM | 0.074 ml | 0.371 ml | 0.742 ml |
| 5 mM | 0.015 ml | 0.074 ml | 0.148 ml |
Last Update：2024-01-02 23:10:35
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide - Nature
| solubility | H2O: 1 mg/mL |
Last Update：2024-04-10 22:29:15
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide - Introduction
SUBSTANCE P is a phosphorus-related SUBSTANCE, which can refer to different compounds depending on the specific chemical structure and function. The following are general properties and information about SUBSTANCE P:
Nature:
1. Phosphate: phosphorus in SUBSTANCE P can exist in different forms, such as phosphate. Phosphates are compounds composed of phosphate ions and metal ions or non-metal ions.
2. Reactivity: SUBSTANCE P can participate in a variety of chemical reactions, for example, react with metal to generate metal phosphide, react with oxygen to generate phosphoric acid, etc.
Use:
1. Agriculture: Phosphate is one of the commonly used agricultural fertilizers, which provides the phosphorus required by plants and promotes plant growth and development.
2. Chemical Industry: SUBSTANCE P can be used to prepare a variety of chemicals, such as phosphoric acid, phosphate, organic phosphorus compounds, etc., these compounds are widely used in fertilizers, pesticides, fire retardant, cleaning agents and other fields.
3. Drugs: Some organophosphorus compounds are used as antibacterial drugs or anticancer drugs.
Preparation Method:
1. Phosphate: common preparation methods include sulfuric acid method and nitric acid method, in which the sulfuric acid method reacts phosphate rock with concentrated sulfuric acid to generate phosphate, and the nitric acid method reacts phosphoric acid and nitric acid to obtain phosphate.
Safety Information:
1. When operating SUBSTANCE P, appropriate protective measures should be taken, such as wearing protective glasses, gloves and protective clothing.
2. Some SUBSTANCE P may be irritating or corrosive. After contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
3. When storing and handling SUBSTANCE P, care should be taken to prevent contact with combustibles or oxidants to avoid fire or explosion.
4. In SUBSTANCE P waste disposal process, to comply with local environmental regulations, and take appropriate measures to prevent pollution to the environment.
Nature:
1. Phosphate: phosphorus in SUBSTANCE P can exist in different forms, such as phosphate. Phosphates are compounds composed of phosphate ions and metal ions or non-metal ions.
2. Reactivity: SUBSTANCE P can participate in a variety of chemical reactions, for example, react with metal to generate metal phosphide, react with oxygen to generate phosphoric acid, etc.
Use:
1. Agriculture: Phosphate is one of the commonly used agricultural fertilizers, which provides the phosphorus required by plants and promotes plant growth and development.
2. Chemical Industry: SUBSTANCE P can be used to prepare a variety of chemicals, such as phosphoric acid, phosphate, organic phosphorus compounds, etc., these compounds are widely used in fertilizers, pesticides, fire retardant, cleaning agents and other fields.
3. Drugs: Some organophosphorus compounds are used as antibacterial drugs or anticancer drugs.
Preparation Method:
1. Phosphate: common preparation methods include sulfuric acid method and nitric acid method, in which the sulfuric acid method reacts phosphate rock with concentrated sulfuric acid to generate phosphate, and the nitric acid method reacts phosphoric acid and nitric acid to obtain phosphate.
Safety Information:
1. When operating SUBSTANCE P, appropriate protective measures should be taken, such as wearing protective glasses, gloves and protective clothing.
2. Some SUBSTANCE P may be irritating or corrosive. After contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
3. When storing and handling SUBSTANCE P, care should be taken to prevent contact with combustibles or oxidants to avoid fire or explosion.
4. In SUBSTANCE P waste disposal process, to comply with local environmental regulations, and take appropriate measures to prevent pollution to the environment.
Last Update：2024-04-09 15:16:27
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide - Uses and synthesis methods
biological activity
Substance P (Neurokinin P) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor for Substance P is the neurokinin 1 receptor (neurokinin 1 receptor,NK1R).
target
Human Endogenous Metabolite
in vitro study
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.
production method
The bovine hypothalamus is used as raw material, homogenized in acetone and hydrochloric acid solution, filtered and extracted with petroleum ether, and refined by column chromatography and paper electrophoresis.
Last Update：2024-04-09 21:54:55
![(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide](http://res.chembk.com/assets/images/structure/33507-63-0.gif)
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Spot supply
Product Name: Substance P Visit Supplier Webpage Request for quotationCAS: 33507-63-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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